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An experimental model of tardive dyskinesias

Clow, Angela and Jenner, Peter and Theodorou, A. and Marsden, C.D. (1978) An experimental model of tardive dyskinesias. Life Sciences, 23 (5). pp. 421-423. ISSN 0024-3205

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Official URL: http://dx.doi.org/10.1016/0024-3205(78)90146-7

Abstract

Rats treated continually and chronically with trifluoperazine (ca 3 mg/kg/day) for six months initially developed mild catalepsy and an inhibition of spontaneous locomotor activity; both effects disappeared by three months. An initial increase in dopamine turnover (as measured by levels of homovanillic acid and dihydroxyphenylacetic acid) also disappeared by three months. Apomorphine-induced stereotypy was completely inhibited in drug-treated animals at two weeks, but progressively returned to normal after three months of drug intake. An exaggerated response to apomorphine developed in animals after six months of drug administration. Inhibition of striatal dopamine-stimulated adenylate cyclase found during the first month of drug intake was reversed at three months, a trend exaggerated after continuous drug administration for six months. Specific striatal 3H-spiperone binding affinity decreased acutely, but was increased after six months drug intake; no change in number of receptor sites occurred. These changes suggest that at least striatal dopamine receptors may become “supersensitive” during chronic neuroleptic treatment.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:10052
Deposited On:07 Dec 2011 11:26
Last Modified:07 Dec 2011 11:26

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