The central role of myostatin in skeletal muscle and whole body homeostasis

Elliott, Bradley T., Renshaw, Derek, Getting, Stephen J. and Mackenzie, Richard W.A. (2012) The central role of myostatin in skeletal muscle and whole body homeostasis. Acta Physiologica, 205 (3). pp. 324-340. ISSN 1748-1716

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Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It plays a key role in skeletal muscle homeostasis and has now been well described since its discovery. Myostatin is capable of inducing muscle atrophy via its inhibition of myoblast proliferation, increasing ubiquitin proteasomal activity and down-regulating activity of the IGF-Akt pathway. These well recognised effects are seen in multiple atrophy causing situations, including injury, diseases such as cachexia, disuse and space flight, demonstrating the importance of the myostatin signalling mechanism. Based on this central role, significant work has been pursued to inhibit myostatin's actions in vivo. Importantly, several new studies have uncovered roles for myostatin distinct from skeletal muscle size. Myostatin has been suggested to play a role in cardiomyocyte homeostasis, glucose metabolism and adipocyte proliferation, all of which are examined in detail below. Based on these effects, myostatin inhibition has potential to be widely utilized in many western diseases such as COPD, type II diabetes and obesity. However, if myostatin inhibitors are to successfully translate from bench-top to bedside in the near future, awareness must be raised on these non-traditional effects of myostatin away from skeletal muscle. Indeed, further research into these novel areas is required.

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 23 Feb 2012 14:49
Last Modified: 03 Jul 2014 09:34

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