Genome-wide association analysis identifies three new breast cancer susceptibility loci

Ghoussaini, Maya, Fletcher, Olivia, Michailidou, Kyriaki, Turnbull, Clare, Schmidt, Marjanka K., Dicks, Ed, Dennis, Joe, Wang, Qin, Humphreys, Manjeet K., Luccarini, Craig, Baynes, Caroline, Conroy, Don, Maranian, Melanie, Ahmed, Shahana, Driver, Kristy, Johnson, Nichola, Orr, Nicholas, Dos Santos Silva, Isabel, Waisfisz, Quinten, Meijers-Heijboer, Hanne, Uitterlinden, Andre G., Rivadeneira, Fernando, Hall , Per, Czene, Kamila, Irwanto, Astrid, Liu, Jianjun, Nevanlinna, Heli, Aittomaki, Kristiina, Blomqvist, Carl, Meindl, Alfons, Schmutzler, Rita K., Muller-Myhsok, Bertram, Lichtner, Peter, Chang-Claude, Jenny, Hein, Rebecca, Nickels, Stefan, Flesch-Janys, Dieter, Tsimiklis, Helen, Makalic, Enes, Schmidt, Daniel, Bui, Minh, Hopper, John L., Apicella, Carmel, Park, Daniel J., Southey , Melissa C., Hunter, David J., Channock, Stephen J., Broeks, Annegien, Verhoef, Senno, Hogervorst, Frans B.L., Fasching, Peter A., Lux, Michael P., Beckmann, Matthias W., Ekici, Arif B., Sawyer, Elinor, Tomlinson, Ian, Kerin, Michael, Marme, Frederick, Schneeweiss, Andreas, Sohn, Christof, Burwinkel, Barbara, Guenel, Pascal, Truong, Therese, Cordina-Duverger, Emilie, Menegaux, Florence, Bojesen, Stig E., Nordestgaard, Borge G., Nielsen, Sune F., Flyger, Henrik, Milne, Roger L., Alonso, M. Rosario, Gonzalez-Neira, Anna, Benitez, Javier, Anton-Culver, Hoda, Ziogas, Argyrios, Bernstein, Leslie, Clarke Dur, Christina, Brenner, Hermann, Muller, Heiko, Arndt, Volker, Stegmaier, Christa, Justenhoven, Christina, Brauch, Hiltrud, Bruning, Thomas, Wang-Gohrke, Shan, Eilber, Ursula, Dork, Thilo, Schurmann, Peter, Bremer, Michael, Hillemanns, Peter, Bogdanova, Natalia V., Antonenkova, Natalia N., Rogov, Yuri i., Karstens, Johann H. , Bermisheva, Marina, Prokofieva, Darya, Khusnutdinova, Elza, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Lambrechts, Diether, Yesilyurt, Betul T. , Floris, Guiseppe, Leunen, Karin, Manoukian, Siranoush, Bonanni, Bernardo, Fortuzzi, Stefano, Peterlongo, Paolo, Couch, Fergus J., Wang , Xianshu, Stevens, Kristen N., Lee, Adam, Giles, Graham G., Baglietto, Laura, Severi, Gianluca, McLean, Catriona A., Grenaker Alnaes, Grethe, Kristensen, Vessela, Borrensen-Dale, Anna-Lise, John , Esther M., Miron, Alexander, Winqvist, Robert, Pylkas, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Glendon, Gord, Mulligan, Anne Marie, Devilee, Peter, van Asperen, Christie J., Tollenaar, R.A.E.M, Seynaeve, Caroline, Figueroa, Jonine D., Garcia-Closas, Montserrat, Brinton, Louise, Lissowska, Jolanta, Hooning, Maartje J., Hollestelle, Antoinette, Oldenburg, Rogier A., van den Ouweland, Ans M. W., Cox, Angela, Reed, Malcolm W.R., Shah, Mitul, Jakubowska, Ania, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Jones, Michael, Schoemaker, Minouk J., Ashworth, Alan, Swerdlow, Anthony J., Beesley, Jonathan, Chen, Xiaoqing, Muir, Kenneth, Lophatananon, Artitaya, Rattanamongkongul, Suthee, Chaiwerawattana, Arkom, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Shen, Chen-Yang, Yu, Jyh-Cherng, Wu, Pei-Ei, Hsiung, Chia-Ni, Perkins, Annie, Swann, Ruth, Velentzis, Louiza S. , Eccles, Diana M., Tapper, Will J., Gerty, Susan M., Graham, Nikki J., Ponder, Bruce A. J., Chenevix-Trench, Georgia, Pharoah, Paul D. P., Lathrop, Mark, Dunning, Alison M., Rahman, Nazneen, Peto, Julian and Easton, Douglas F. (2012) Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nature Genetics, 44 (3). pp. 312-318. ISSN 1546-1718

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Official URL: http://dx.doi.org/10.1038/ng.1049

Abstract

Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ?8% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in ?70,000 cases and ?68,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 × 10(-35)), 12q24 (rs1292011; P = 4.3 × 10(-19)) and 21q21 (rs2823093; P = 1.1 × 10(-12)). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth.

Item Type: Article
Additional Information: Netherlands Collaborative Group on Hereditary Breast and Ovarian Cancer (HEBON), Familial Breast Cancer Study (FBCS), The Gene Environment Interaction of Breast Cancer in Germany (GENICA) Network, kConFab Investigators, Australian Ovarian Cancer Study Group are also listed as authors
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Rachel Wheelhouse
Date Deposited: 09 Mar 2012 14:36
Last Modified: 27 Aug 2014 11:25
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/10354

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