Brooks, S.A., Carter, T.M., Royle, Louise, Harvey, D.J., Fry, Simon, Kinch, C., Dwek, Raymond A. and Rudd , Pauline M. (2008) Altered glycosylation of proteins in cancer: what is the potential for new anti-tumour strategies. Anti-Cancer Agents in Medicinal Chemistry, 8 (1). pp. 2-21. ISSN 1871-5206Full text not available from this repository.
It is becoming increasingly apparent that cell surface oligosaccharides play pivotal roles as recognition molecules in a range of cell communication and adhesion processes. Alterations in cellular glycosylation are also associated with diseases, including cancer, and may have functional significance. This paper gives an overview of the complex topic of cellular glycosylation mechanisms and reviews the well-documented alterations in cellular glycosylation of proteins in malignancy. One particular type of cancer-associated glycosylation change, the incomplete synthesis of O-linked glycans, is highlighted, and its possible functional significance in cancer cell metastatic mechanisms is discussed. The significance that cancer-associated changes in glycoprotein glycosylation may have in new approaches to anti-tumour therapies is explored.
|Subjects:||University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)|
|Depositing User:||Rachel Wheelhouse|
|Date Deposited:||13 Mar 2012 14:30|
|Last Modified:||13 Mar 2012 14:52|
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