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Beyond the genome and proteome: targeting protein modifications in cancer

Markiv, Anatoliy and Rambaruth, Neela D.S. and Dwek, Miriam (2012) Beyond the genome and proteome: targeting protein modifications in cancer. Current Opinions in Pharmacology., 12 (4). pp. 408-413. ISSN 1471-4892

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Official URL: http://dx.doi.org/10.1016/j.coph.2012.04.003

Abstract

Nearly all proteins are modified in post translational events, indeed, understanding the control and function of post translational modifications (PTMs) is arguably the ‘next frontier’ for cancer cell biologists. The most well understood PTMs include glycosylation, phosphorylation, ubiquitination, methylation and palmitylation. Each of these modifications has been observed to be altered in cancer, affecting key cellular pathways including signal transduction, cell membrane receptor function, and protein–protein interactions. A number of strategies have been proposed that aim to target the modified proteins themselves, the enzymes that construct them, or that boost host-cellular immunity against modified residues aberrantly expressed in cancer.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:10422
Deposited On:24 Apr 2012 11:47
Last Modified:16 Jul 2013 10:28

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