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The presence of NK3 tachykinin receptors on rat uterus

Barr, Alastair J. and Watson, Steve P. and Bernal, Andres Lopez and Nimmo, Alan J. (1991) The presence of NK3 tachykinin receptors on rat uterus. European Journal of Pharmacology, 203 (2). pp. 287-290. ISSN 0014-2999

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Official URL: http://dx.doi.org/10.1016/0014-2999(91)90726-7


The NK3 agonist, senktide, induced a potent contraction of rat uterus in the presence of tetrodotoxin, atropine and indomethacin, or the tachykinin receptor antagonists L-659877 and [D-Pro4, D-Trp7,9,10] substance P (4–11). Additional contractile and radioligand binding studies with receptor selective agonists and antagonists confirmed the presence of NK3 receptors and also revealed the presence of NK1 and NK2 receptors. The rat uterus is the second peripheral tissue in which a post-synaptic, non-neuronal NK3 receptor has been identified.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:10859
Deposited On:20 Jul 2012 13:42
Last Modified:20 Jul 2012 13:42

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