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Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development

Barr, Alastair J. (2010) Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development. Future Medicinal Chemistry, 2 (10). pp. 1563-1576. ISSN 1756-8919

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Official URL: http://dx.doi.org/10.4155/fmc.10.241

Abstract

Several 'classical' protein tyrosine phosphatases are attractive therapeutic targets, including PTP1B for obesity and Type II diabetes; SHP2 for cancer and Lyp for rheumatoid arthritis. Progress has been made in identifying a broad range of chemically distinct inhibitors; however, developing selective and cell-permeable clinically useful compounds has proved challenging. Here the ongoing challenges and recent significant advances in the field are reviewed. Key novel compounds are highlighted and a perspective on the future of phosphatase inhibitor development is presented.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:10879
Deposited On:20 Jul 2012 15:59
Last Modified:11 Jun 2013 11:08

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