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Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics

Getting, Stephen J. and Perretti, Mauro (2001) Arthritic diseases: melanocortin type 3 receptor agonists as potential therapeutics. Current opinion in investigational drugs, 2 (8). pp. 1064-1069. ISSN 1472-4472

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Gouty arthritis is currently treated with drugs that have an array of side effects. Therefore, identification of novel endogenous targets for drug development may have beneficial properties ACTH4-10, a heptapeptide fragment derived from the hormone adrenocorticotrophin (ACTH) modulates the inflammatory response in a corticosterone-independent manner, via agonism at melanocortin type 3 receptors (MC3-R) expressed on peritoneal macrophages. MC3-R agonists inhibit cytokine formation and subsequent neutrophil migration, while antagonists abrogate these effects. Together, these data highlight MC3-R as a potential therapeutic target and suggest that small molecule agonists directed at MC3-R with more specific actions, may be potentially novel therapeutics for treating this pathology.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:10899
Deposited On:24 Jul 2012 10:15
Last Modified:24 Jul 2012 10:15

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