TIS11 family proteins and their roles in post-transcriptional gene regulation

Baou, Maria and Jewell, Andrew P. and Murphy, John J. (2009) TIS11 family proteins and their roles in post-transcriptional gene regulation. Journal of Biomedicine and Biotechnology. Article ID 634520. ISSN 1110-7243

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Official URL: http://dx.doi.org/10.1155/2009/634520


Posttranscriptional regulation of gene expression of mRNAs containing adenine-uridine rich elements (AREs) in their untranslated regions is mediated by a number of different proteins that interact with these elements to either stabilise or destabilise them. The present review concerns the TPA-inducible sequence 11 (TIS11) protein family, a small family of proteins, that appears to interact with ARE-containing mRNAs and promote their degradation. This family of proteins has been extensively studied in the past decade. Studies have focussed on determining their biochemical functions, identifying their target mRNAs, and determining their roles in cell functions and diseases.

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Rachel Wheelhouse
Date Deposited: 16 Oct 2012 14:44
Last Modified: 11 Jun 2013 10:53
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/11203

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