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TIS11 family proteins and their roles in post-transcriptional gene regulation

Baou, Maria and Jewell, Andrew P. and Murphy, John J. (2009) TIS11 family proteins and their roles in post-transcriptional gene regulation. Journal of Biomedicine and Biotechnology . Article ID 634520. ISSN 1110-7243

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Official URL: http://dx.doi.org/10.1155/2009/634520

Abstract

Posttranscriptional regulation of gene expression of mRNAs containing adenine-uridine rich elements (AREs) in their untranslated regions is mediated by a number of different proteins that interact with these elements to either stabilise or destabilise them. The present review concerns the TPA-inducible sequence 11 (TIS11) protein family, a small family of proteins, that appears to interact with ARE-containing mRNAs and promote their degradation. This family of proteins has been extensively studied in the past decade. Studies have focussed on determining their biochemical functions, identifying their target mRNAs, and determining their roles in cell functions and diseases.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:11203
Deposited On:16 Oct 2012 15:44
Last Modified:11 Jun 2013 11:53

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