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Genetic analysis of the pnp–deaD genetic region reveals membrane lipoprotein NlpI as an independent participant in cold acclimatization of Salmonella enterica serovar Typhimurium

Fazle Rouf, Syed and Anwar, Naeem and Clements, Mark O. and Rhen, Mikael (2011) Genetic analysis of the pnp–deaD genetic region reveals membrane lipoprotein NlpI as an independent participant in cold acclimatization of Salmonella enterica serovar Typhimurium. FEMS Microbiology Letters, 325 (1). pp. 56-63. ISSN 0378-1097

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Official URL: http://dx.doi.org/10.1111/j.1574-6968.2011.02416.x

Abstract

The cold acclimatization response in many bacterial species is a tightly regulated process, which ensures the correct folding of macromolecules. In enterobacteria, this response is in part dependent on polynucleotide phosphorylase, which is encoded by the gene pnp. Based on transcriptional analysis of the pnp locus of Salmonella enterica serovar Typhimurium, we show that pnp and the adjacent membrane lipoprotein nlpI gene form an operon with both genes contributing independently to the cold acclimatization response at 15 °C. Our findings thereby define a new role for NlpI in bacterial cold acclimatization.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:11260
Deposited On:23 Oct 2012 11:32
Last Modified:23 Oct 2012 11:33

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