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Differential suppression of tumor-specific CD8+ T cells by regulatory T cells

James, Edward and Yeh, Alex and King, Cathy and Korangy, Firouzeh and Bailey, Ian and Boulanger, Denise S. and Van den Eynde, Benoît J. and Murray, Nicholas and Elliott, Tim J. (2010) Differential suppression of tumor-specific CD8+ T cells by regulatory T cells. Journal of Immunology, 185 (9). pp. 5048-5055. ISSN 0022-1767

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Official URL: http://dx.doi.org/10.4049/jimmunol.1000134

Abstract

In the CT26 BALB/c murine model of colorectal carcinoma, depletion of regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity to both CT26 and other BALB/c-derived tumors of diverse histological origin. In this paper, we show that cross-protection can be conferred by adoptively transferred CD8+ CTLs. Other schedules for inducing immunity to CT26 have been described, but they do not lead to cross-protection. We show that Treg ablation facilitates the development of new CTL specificities that are normally cryptic, and have mapped the root epitope of one of these responses. This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:11277
Deposited On:23 Oct 2012 14:58
Last Modified:23 Oct 2012 14:58

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