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Genomic biomarkers for patient selection and stratification: the cancer paradigm

Moschos, Sterghios A. (2012) Genomic biomarkers for patient selection and stratification: the cancer paradigm. Bioanalysis, 4 (20). pp. 2499-2511. ISSN 1757-6180

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Official URL: http://dx.doi.org/10.4155/bio.12.241

Abstract

The revolution in disease diagnosis and treatment promised on the completion of the human genome project over a decade ago has materialized in the form of unified drug and biomarker discovery and development pipelines. This strategic shift has been principally catalyzed through success stories in the field of oncology, ushering in the era of personalized medicine. Thus, a number of molecular targets have also been demonstrated to be reliable markers for selecting patients wherein treatment can be efficacious. Perhaps more importantly, however, the late adoption of biomarker strategies has also rescued drug candidates from complete late-stage failure. This review examines the historical lessons of key challenges in translating biomarker assay information into strategic and clinically actionable decisions and assesses the impact of personalized genome sequencing in the future of companion diagnostic development and commercialization.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:11518
Deposited On:16 Nov 2012 10:59
Last Modified:09 May 2013 12:28

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