Attenuation of plasma annexin A1 in human obesity

Kosicka, Anna, Cunliffe, Adam, Mackenzie, Richard W.A., Gulrez Zariwala, M. , Perretti, Mauro, Flower, Roderick J. and Renshaw, Derek (2013) Attenuation of plasma annexin A1 in human obesity. FASEB Journal, 27 (1). pp. 368-378. ISSN 0892-6638

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Official URL: http://dx.doi.org/10.1096/fj.12-213728

Abstract

Obesity-related metabolic disorders are characterized by mild chronic inflammation, leukocyte infiltration, and tissue fibrosis as a result of adipocytokine production from the expanding white adipose tissue. Annexin A1 (AnxA1) is an endogenous glucocorticoid regulated protein, which modulates systemic anti-inflammatory processes and, therefore, may be altered with increasing adiposity in humans. Paradoxically, we found that plasma AnxA1 concentrations inversely correlated with BMI, total percentage body fat, and waist-to-hip ratio in human subjects. Plasma AnxA1 was also inversely correlated with plasma concentrations of the acute-phase protein, C-reactive protein (CRP), and the adipocytokine leptin, suggesting that as systemic inflammation increases, anti-inflammatory AnxA1 is reduced. In addition, AnxA1 gene expression and protein were significantly up-regulated during adipogenesis in a human adipocyte cell line compared to vehicle alone, demonstrating for the first time that AnxA1 is expressed and excreted from human adipocytes. These data demonstrate a failure in the endogenous anti-inflammatory system to respond to increasing systemic inflammation resulting from expanding adipose tissue, a condition strongly linked to the development of type 2 diabetes and cardiovascular disease. These data raise the possibility that a reduction in plasma AnxA1 may contribute to the chronic inflammatory phenotype observed in human obesity.

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Rachel Wheelhouse
Date Deposited: 07 Jun 2013 14:14
Last Modified: 07 Jun 2013 14:14
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/12518

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