The roles of melanin-concentrating hormone in energy balance and reproductive function: are they connected?

Naufahu, Jane, Cunliffe, Adam and Murray, Joanne F. (2013) The roles of melanin-concentrating hormone in energy balance and reproductive function: are they connected? Reproduction, 146. R141-R150. ISSN 1470-1626

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Official URL: http://dx.doi.org/10.1530/REP-12-0385

Abstract

Melanin concentrating hormone (MCH) is an anabolic neuropeptide with multiple and diverse physiologic functions including a key role in energy homeostasis. Rodent studies have shown that ablation of functional MCH results in a lean phenotype, increased energy expenditure and resistance to diet-induced obesity. These findings have generated interest amongst pharmaceutical companies vigilant for potential anti-obesity agents. Nutritional status impacts on reproductive physiology and behaviours thereby optimising reproductive success and the ability to meet energetic demands. This complex control system entails integration of direct or indirect peripheral stimuli with central effector systems and involves numerous mediators. A role for MCH in the reproductive axis has emerged giving rise to the premise that MCH may serve as an integratory mediator between those discrete systems which regulate energy balance and reproductive function. Hence this review focuses on published evidence concerning a) the role of MCH in energy homeostasis and b) the regulatory role of MCH in the reproductive axis. The question as to whether the MCH system mediates the integration of energy homeostasis with the neuroendocrine reproductive axis and if so by what means has received limited coverage in the literature; evidence to date and current theories are summarised here.

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 06 Aug 2013 13:32
Last Modified: 28 Jan 2014 15:00
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/12849

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