Synthesis, characterization and comparative study of aminophosphonate chelates of gadolinium(III) ions as magnetic resonance imaging contrast agents

Bligh, S.W. Annie, Harding, Charles T., McEwen, Andrew B. and Sadler, Peter J. (1994) Synthesis, characterization and comparative study of aminophosphonate chelates of gadolinium(III) ions as magnetic resonance imaging contrast agents. Polyhedron, 13 (12). pp. 1937-1943. ISSN 0277-5387

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Official URL: http://dx.doi.org/10.1016/0277-5387(94)80018-9

Abstract

Gadolinium(III) complexes of aminophosphonates, including a novel ligand L4H8, have been investigated as potential contrast agents for NMR imaging. Water 1H relaxivities at 10 and 200 MHz were determined and luminescence measurements, on TbIII complexes, allowed the determination of the number of coordinated H2O molecules. The complexes bound strongly to hydroxyapatite, suggesting possible targetting to bone in vivo. This was confirmed by 153Gd tracer studies with the most favourable biodistribution in rats being shown by gadolinium(III) ethylenediamine-N,N,N?,N?-tetrakis(methylenephosphonate).

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Rachel Wheelhouse
Date Deposited: 06 Jan 2014 15:02
Last Modified: 06 Jan 2014 15:02
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/13498

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