MRI assessment of the blood-brain barrier in a hamster model of scrapie

Chung, Yuen-Li, Williams, Alun, Beech, John S., Williams, Steve C.R., Bell, Jimmy D., Cox, I. Jane and Hope, James (1995) MRI assessment of the blood-brain barrier in a hamster model of scrapie. Neurodegeneration, 4 (2). pp. 203-207. ISSN 1055-8330

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Official URL: http://dx.doi.org/10.1006/neur.1995.0025

Abstract

Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 21 Aug 2014 11:10
Last Modified: 21 Aug 2014 11:10
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/14160

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