Neonatal intrahepatocellular lipid

Thomas, E. Louise, Uthaya, Sabita N., Vasu, Vimal, McCarthy, John, McEwan, P., Hamilton, Gavin, Bell, Jimmy D. and Modi, Neena (2008) Neonatal intrahepatocellular lipid. Archives of Disease in Childhood. Fetal and Neonatal Edition, 93 (5). F382-F383. ISSN 1359-2998

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Official URL: http://fn.bmj.com/content/93/5/F382.abstract

Abstract

There is increasing evidence that preterm birth is a risk factor for the development of adiposity associated disease, although the pathophysiological basis is unclear. We have previously shown that preterm infants have increased internal abdominal (visceral) adiposity by term. In adults increased internal adiposity is associated with elevated intrahepatocellular lipid (IHCL). We measured IHCL using 1H NMR spectroscopy in 26 infants (eight healthy preterm-at-term and 18 term-born) and compared values with a reference group of 32 adults. There was no significant difference between adult and term-born IHCL content. In preterm-at-term infants IHCL was significantly elevated when compared with term-born infants and with adults (IHCL CH2/water median (interquartile range): preterm 1.69 (1.04–3.53), term 0.21 (0–0.54) and adult 0.55 (0.08–1.57).

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Rachel Wheelhouse
Date Deposited: 26 Aug 2014 15:46
Last Modified: 28 Aug 2014 14:11
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/14229

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