Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering

Meng, Decheng, Francis, Lydia, Thompson, I.D., Mierke, C., Huebner, H., Amtmann, A., Roy, Ipsita and Boccaccini, Aldo R. (2013) Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass®-based scaffolds for bone tissue engineering. Journal of Materials Science: Materials in Medicine, 24 (12). pp. 2809-2817. ISSN 0957-4530

Full text not available from this repository.
Official URL: http://dx.doi.org/10.1007/s10856-013-5012-4

Abstract

Bioglass(®)-based scaffolds for bone tissue engineering have been developed, which can also serve as carriers for drug delivery. For this, P(3HB) microspheres (PMSs) loaded with tetracycline were fabricated and immobilised on the scaffold surfaces by a modified slurry dipping technique. The sustained drug delivery ability in simulated body fluid was confirmed by using UV-Vis absorption spectroscopy measurements. The MTT assay using mouse fibroblast cells provided evidence that the tetracycline loaded microspheres produced in this study show limited cytotoxicity. The scaffolds developed in this work provide mechanical support, adequate 3D surface roughness, bioactivity and controlled drug delivery function, and are thus interesting candidates for bone tissue engineering applications.

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Rachel Wheelhouse
Date Deposited: 22 Sep 2014 14:12
Last Modified: 22 Sep 2014 14:12
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/14390

Actions (login required)

Edit Item (Repository staff only) Edit Item (Repository staff only)