Colonic bacterial metabolites and host health

Russell, W., Hoyles, L., Flint, H. J. and Dumas, M.-E. (2013) Colonic bacterial metabolites and host health. Current Opinion in Microbiology, 16 (3). pp. 246-254.

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The influence of the microbial-mammalian metabolic axis is becoming increasingly important for human health. Bacterial fermentation of carbohydrates (CHOs) and proteins produces short-chain fatty acids (SCFA) and a range of other metabolites including those from aromatic amino acid (AAA) fermentation. SCFA influence host health as energy sources and via multiple signalling mechanisms. Bacterial transformation of fibre-related phytochemicals is associated with a reduced incidence of several chronic diseases. The 'gut-liver axis' is an emerging area of study. Microbial deconjugation of xenobiotics and release of aromatic moieties into the colon can have a wide range of physiological consequences. In addition, the role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease (NAFLD) and insulin resistance is receiving increased attention.

Item Type: Article
Subjects: University of Westminster > Science and Technology
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Date Deposited: 19 Jun 2015 10:22
Last Modified: 23 Feb 2016 16:07

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