Clements, Mark O. and Eriksson, Sofia and Thompson, Arthur and Lucchini, Sacha and Hinton, Jay C. D. and Normark, Staffan J. and Rhen, Mikael (2002) Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica. Proceedings of the National Academy of Sciences of the United States of America, 99 (13). pp. 8784-8789. ISSN 0027-8424
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Official URL: http://www.pnas.org/cgi/doi/10.1073/pnas.132047099
For many pathogens, the ability to regulate their replication in host cells is a key element in establishing persistency. Here, we identified a single point mutation in the gene for polynucleotide phosphorylase (PNPase) as a factor affecting bacterial invasion and intracellular replication, and which determines the alternation between acute or persistent infection in a mouse model for Salmonella enterica infection. In parallel, with microarray analysis, PNPase was found to affect the mRNA levels of a subset of virulence genes, in particular those contained in Salmonella pathogenicity islands 1 and 2. The results demonstrate a connection between PNPase and Salmonella virulence and show that alterations in PNPase activity could represent a strategy for the establishment of persistency. Copyright (2002) National Academy of Sciences, U.S.A.
|Additional Information:||Online ISSN 1091-6490|
|Research Community:||University of Westminster > Life Sciences, School of|
|Deposited On:||12 May 2006|
|Last Modified:||16 Dec 2009 12:57|
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