Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly

Wang, Fei, Ruther, Paul, Jiang, Ivy, Sawada-Hirai, Ritsuko, Sun, Shu Man, Nedellec, Rebecca, Morrow, Phillip R. and Kang, Angray S. (2004) Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly. Human Antibodies, 13 (4). pp. 105-110. ISSN 1093-2607

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Abstract

A panel of human anti-anthrax protective antigen IgG1 monoclonal antibodies were evaluated to determine the mechanism of toxin neutralization. AVP-22G12, AVP-1C6 and AVP-21D9 bound to the protective antigen with picomolar affinities to distinct non-overlapping linear epitopes. Two of the antibodies neutralized the anthrax toxin by completely inhibiting the protective antigen oligomer assembly process in vitro.

Item Type: Article
Uncontrolled Keywords: Human monoclonal antibodies, bacillus anthracis, protective antigen
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 12 May 2006
Last Modified: 11 Aug 2010 14:30
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/1544

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