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Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly

Wang, Fei and Ruther, Paul and Jiang, Ivy and Sawada-Hirai, Ritsuko and Sun, Shu Man and Nedellec, Rebecca and Morrow, Phillip R. and Kang, Angray S. (2004) Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly. Human Antibodies, 13 (4). pp. 105-110. ISSN 1093-2607

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Abstract

A panel of human anti-anthrax protective antigen IgG1 monoclonal antibodies were evaluated to determine the mechanism of toxin neutralization. AVP-22G12, AVP-1C6 and AVP-21D9 bound to the protective antigen with picomolar affinities to distinct non-overlapping linear epitopes. Two of the antibodies neutralized the anthrax toxin by completely inhibiting the protective antigen oligomer assembly process in vitro.

Item Type:Article
Uncontrolled Keywords:Human monoclonal antibodies, bacillus anthracis, protective antigen
Research Community:University of Westminster > Life Sciences, School of
ID Code:1544
Deposited On:12 May 2006
Last Modified:11 Aug 2010 15:30

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