WestminsterResearch will not be accepting deposits until 9th March 2015. This is to allow for a system upgrade and server migration.

An investigation into asymmetrical cortical regulation of salivary S-IgA in conscious man using transcranial magnetic stimulation

Clow, Angela and Lambert, Shirley and Evans, Philip D. and Hucklebridge, Frank and Higuchi, Kazuo (2003) An investigation into asymmetrical cortical regulation of salivary S-IgA in conscious man using transcranial magnetic stimulation. International Journal of Psychophysiology, 47 (1). pp. 57-64. ISSN 0167-8760

Full text not available from this repository.

Official URL: http://dx.doi.org/10.1016/S0167-8760(02)00093-4


Transcranial magnetic stimulation (TMS) can activate discrete areas of the cerebral cortex through the intact skull of healthy conscious volunteers. A magnetic coil generates a brief and focused magnetic field that penetrates the skull to activate the specific area of cerebral cortex beneath. This non-invasive procedure is painless, well tolerated by participants and now widely used to explore brain function. We used TMS to investigate asymmetrical cortical regulatory influences on one aspect of immune function: secretion of the antibody immunoglobulin A (S-IgA) into saliva. The right and left temporo-parietal-occipital cortex of 16 healthy, conscious subjects was stimulated on two different occasions, at least 1 week apart. There was an immediate increase in S-IgA concentration following both right and left stimulation. Saliva volume was reduced immediately post-right but not left stimulation. When secretion (μg/min) of S-IgA was calculated (controlling for changing saliva volume) an increase was apparent following left but not right hemisphere stimulation. Furthermore, a significant difference between the relationship between S-IgA concentration and volume of saliva post-left and right stimulation was observed. We conclude that TMS can be used as a tool to investigate cortical regulation of autonomic and immune function in healthy, conscious human subjects and that secretion of saliva and S-IgA is differentially affected by stimulation of the left and right cerebral cortex.

Item Type:Article
Uncontrolled Keywords:S-IgA; Saliva, Transcranial magnetic stimulation, Human, Cerebral cortex, Asymmetrical
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
University of Westminster > Life Sciences, School of
ID Code:159
Deposited On:05 Dec 2005
Last Modified:04 Nov 2009 14:34

Repository Staff Only: item control page