Aloe vera for preventing radiation-induced skin reactions: a systematic literature review

Richardson, Janet, Smith, Joanna E., McIntyre, Michael, Thomas, Robert and Pilkington, Karen (2005) Aloe vera for preventing radiation-induced skin reactions: a systematic literature review. Clinical Oncology, 17 (6). pp. 478-484. ISSN 0936-6555

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Aim: To systematically review and critically appraise the evidence for effectiveness of Aloe vera gel for radiation-induced skin reactions. Materials and methods: Major biomedical databases and specialist complementary and alternative medicine databases were searched. Additionally, efforts were made to identify unpublished and ongoing research. Relevant research was systematically categorised by study type and appraised according to study design. Clinical commentaries were obtained for each study included in the review. Results: One earlier systematic review on Aloe vera for a variety of conditions was located. Five published randomised-controlled trials (RCTs) were found, along with two additional RCTs that are not published. No non-RCTs, uncontrolled studies or qualitative studies were found. Conclusions: There is no evidence from clinical trials to suggest that topical Aloe vera is effective in preventing or minimising radiation-induced skin reactions in cancer patients. Further methodologically rigorous, sufficiently powered research studies should be conducted to evaluate the effectiveness of currently used and novel therapies for the prevention, minimisation and management of radiation-induced skin reactions.

Item Type: Article
Additional Information: Online ISSN 1433-2981
Uncontrolled Keywords: Aloe vera, cancer, complementary therapy, radiotherapy, skin reaction, systematic review
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 19 May 2006
Last Modified: 10 Oct 2008 11:21

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