Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase

Rossiter, Sharon, Smith, Caroline L., Malaki, Mohammed, Nandi, Manasi, Gill, Herpreet, Leiper, James M., Vallance, Patrick and Selwood, David L. (2005) Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase. Journal of Medicinal Chemistry, 48 (14). pp. 1670-1678. ISSN 0022-2623

Full text not available from this repository.
Official URL:


The enzyme DDAH metabolizes methylarginines that are inhibitors of nitric oxide synthase (NOS). Substrate-based inhibitors of mammalian DDAH have been synthesized, with optimization to give selective inhibition of DDAH with no significant direct effect on NOSs. These are the first examples of reversible DDAH inhibitors with significant activity and selectivity. In vivo administration increases plasma ADMA levels, giving proof of concept that these inhibitors can be used to probe the physiological effects of DDAH inhibition, with potential for pharmaceutical use of DDAH inhibitors in diseases where excess NO production is implicated.

Item Type: Article
Additional Information: Online ISSN 1520-4804
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 30 May 2006
Last Modified: 07 Apr 2008 13:26

Actions (login required)

Edit Item (Repository staff only) Edit Item (Repository staff only)