Characterization of three human sec14p-like proteins: a-Tocopherol

Zingg, J.M., Kempna, P., Paris, M., Reiter, E., Villacorta, L., Cipollone, R., Munteanu, A., De Pascale, C., Menini, S., Cueff, A., Arock, M., Azzi, A. and Ricciarelli, R. 2008. Characterization of three human sec14p-like proteins: a-Tocopherol. Biochimie . 90 (11-12), p. 1703–1715. https://doi.org/10.1016/j.biochi.2008.07.008

TitleCharacterization of three human sec14p-like proteins: a-Tocopherol
AuthorsZingg, J.M., Kempna, P., Paris, M., Reiter, E., Villacorta, L., Cipollone, R., Munteanu, A., De Pascale, C., Menini, S., Cueff, A., Arock, M., Azzi, A. and Ricciarelli, R.
Abstract

Three closely related human sec14p-like proteins (hTAP1, 2, and 3, or SEC14L2, 3, and 4, respectively) have been described. These proteins may participate in intracellular lipid transport (phospholipids, squalene, tocopherol analogues and derivatives) or influence regulatory lipid-dependent events. Here, we show that the three recombinant hTAP proteins associate with the Golgi apparatus and mitochondria, and enhance the in vitro transport of radioactively labeled α-tocopherol to mitochondria in the same order of magnitude as the human α-tocopherol transfer protein (α-TTP). hTAP1 and hTAP2 are expressed in several cell lines, whereas the expression level of hTAP3 is low. Expression of hTAP1 is induced in human umbilical cord blood-derived mast cells upon differentiation by interleukin 4. In tissues, the three hTAPs are detectable ubiquitously at low level; pronounced and localized expression is found for hTAP2 and hTAP3 in the perinuclear region in cerebellum, lung, liver and adrenal gland. hTAP3 is well expressed in the epithelial duct cells of several glands, in ovary in endothelial cells of small arteries as well as in granulosa and thecal cells, and in testis in Leydig cells. Thus, the three hTAPs may mediate lipid uptake, secretion, presentation, and sub-cellular localization in a tissue-specific manner, possibly using organelle- and enzyme-specific docking sites.

JournalBiochimie
Journal citation90 (11-12), p. 1703–1715
ISSN0300-9084
Year2008
PublisherElsevier
Digital Object Identifier (DOI)https://doi.org/10.1016/j.biochi.2008.07.008
Publication dates
Published05 Aug 2008

Related outputs

Populated Collagen Hydrogel and Polyhydroxyalkanoate Composites: Novel Matrices for Cartilage Repair and Regeneration?
De Pascale, C., Marcello, E., Getting, S.J., Roy, I. and Locke, I.C. Forthcoming. Populated Collagen Hydrogel and Polyhydroxyalkanoate Composites: Novel Matrices for Cartilage Repair and Regeneration? OARSI World Congress on Osteoarthritis . Toronto, Canada 02 Mar - 05 May 2019

Effect of Urocortin on human osteoclasts differentiation
De Pascale, C. 2018. Effect of Urocortin on human osteoclasts differentiation. Getting, S.J. and Locke, I.C. (ed.) British Pharmacological Society Meeting. the Queen Elizabeth II Conference Centre 18 - 20 Dec 2018 British Pharmacological Society.

Influence of chylomicron remnants on human monocyte activation in vitro
Bentley, C., Hathaway, N., Widdows, J., Bejta, F., De Pascale, C., Avella, M., Wheeler-Jones, C.P.D., Botham, K.M. and Lawson, C. 2011. Influence of chylomicron remnants on human monocyte activation in vitro. Nutr Metab Cardiovasc Dis.. 21 (11), pp. 871-878. https://doi.org/10.1016/j.numecd.2010.02.019

Suppression of nuclear factor-kappaB activity in macrophages by chylomicron
De Pascale, C., Graham, V., Fowkes, R.C., Wheeler-Jones, C.P. and Botham, K.M. 2010. Suppression of nuclear factor-kappaB activity in macrophages by chylomicron. European Atherosclerosis Society Meeting . Hamburg, germany 20 - 23 Jun 2010 Elsevier. https://doi.org/10.1016/S1567-5688(10)70301-9

P221 lipid droplets in human macrophages recruit cytosolic phospholipase A2 and promote secretion of inflammatory mediators
De Pascale, C., Bostrom, P., Wickström, Y., Mogensen, C., MattssonHultén, L., Perkins, R., Ståhlman, M., Wiklund, O., Olofsson, S.-O. and Borén, J. 2010. P221 lipid droplets in human macrophages recruit cytosolic phospholipase A2 and promote secretion of inflammatory mediators. European Atherosclerosis Society (EAS) Conference. Hamburg 20 - 23 Jun 2010 Elsevier. https://doi.org/10.1016/S1567-5688(10)70288-9

Modulation of CYP1A1 by PKC Inhibitors and TPA Pre-Treatments in MH1C1 Rat Hepatoma Cells Exposed to 3 -Methylcholanthrene
De Pascale, C., Domenicotti, C., Nitti, M., Marengo, B., Catalano, M., Scanarotti, C., Sanguineti, R., Siri, M., Ledda, S., Penco, S. and Bassi, A. 2009. Modulation of CYP1A1 by PKC Inhibitors and TPA Pre-Treatments in MH1C1 Rat Hepatoma Cells Exposed to 3 -Methylcholanthrene. The Open Toxicology Journal . (3), pp. 47-57. https://doi.org/10.2174/1874340400903010047

Suppression of nuclear factor-κB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles
De Pascale, C., Graham, V., Fowkes, R.C., Wheeler-Jones, C.P.D. and Botham, K.M. 2009. Suppression of nuclear factor-κB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles. FEBS Journal. 276 (19), pp. 5689-5702. https://doi.org/10.1111/j.1742-4658.2009.07260.x

The induction of macrophages foam cell formation by chylomicron remnants
Botham, K.M., Moore, E.H., De Pascale, C. and Bejta, F. 2007. The induction of macrophages foam cell formation by chylomicron remnants. Biochemical Society Transactions. 35 (3), pp. 454-458. https://doi.org/10.1042/BST0350454

Dietary fats induce human monocyte activation in vitro
Bentley, C., Bejta, F., De Pascale, C., Avella, M., Wheeler-Jones, C.P.D., Botham, K.M. and Lawson, C. 2007. Dietary fats induce human monocyte activation in vitro. Biochemical Society Transactions. 35 (3), pp. 464-465. https://doi.org/10.1042/BST0350464

Effects of lycopene on the induction of foam cell formation by modified LDL.
Napolitano, M., De Pascale, C., Wheeler-Jones, C., Botham, K.M. and Bravo, E. 2007. Effects of lycopene on the induction of foam cell formation by modified LDL. American Journal of Physiology: Endocrinology and Metabolism. 293 (6), pp. E1820-7. https://doi.org/10.1152/ajpendo.00315.2007

Increased expression of transglutaminase-1 and PPARgamma after vitamin E treatment in human keratinocytes
De Pascale, M.C., Bassi, A.M., Patrone, V., Villacorta, L., Azzi, A. and Zing, J.M. 2006. Increased expression of transglutaminase-1 and PPARgamma after vitamin E treatment in human keratinocytes. Archives of Biochemistry and Biophysics. 447 (2), pp. 97-106. https://doi.org/10.1016/j.abb.2006.02.002

Fatty acids composition of Chylomicron remnants like particles influences their uptake and induction of lipid accumulation in macrophages.
De Pascale, C., Avella, M., Perona, J.S., Ruiz-Gutierrez, V., Wheeler-Jones, C.P.D. and Botham, K.M. 2006. Fatty acids composition of Chylomicron remnants like particles influences their uptake and induction of lipid accumulation in macrophages. FEBS Journal . 273 (24), p. 5632–5640. https://doi.org/10.1111/j.1742-4658.2006.05552.x

Antioxidant status in J774A.1 macrophage cell line during chronic exposure to glycated serum
Bassi, A.M., Ledda, S., De Pascale, M.C., Penco, S., Rossi, S., Odetti, P. and Cottalasso, D. 2005. Antioxidant status in J774A.1 macrophage cell line during chronic exposure to glycated serum. Biochemistry and Cell Biology. 83 (2), pp. 176-87. https://doi.org/10.1139/o05-024

Damaging effects of advanced glycation end product in the murine macrophages cell line J774A.1.
Bassi, A.M., Ledda, S., Valentini, S., De Pascale, M.C., Rossi, S., Odetti, P. and Cottalasso, D. 2002. Damaging effects of advanced glycation end product in the murine macrophages cell line J774A.1. Toxicology In Vitro. 16 (4), pp. 339-347. https://doi.org/10.1016/S0887-2333(02)00016-4

Permalink - https://westminsterresearch.westminster.ac.uk/item/9y207/characterization-of-three-human-sec14p-like-proteins-a-tocopherol


Share this

Usage statistics

78 total views
0 total downloads
These values cover views and downloads from WestminsterResearch and are for the period from September 2nd 2018, when this repository was created.