Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects

Brody, L.P., Sahuri Arisoylu, M., Parkinson, J.R., Parkes, H.G., So, P-W, Hajji, N, Thomas, E.L., Frost, G.S., Miller, A.D. and Bell, J.D. (2017) Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects. International Journal of Nanomedicine, 12. pp. 6677-6685. ISSN 1176-9114

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Official URL: https://dx.doi.org/10.2147/IJN.S135968

Abstract

Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA)-encapsulated lipid-based delivery system – liposome-encapsulated acetate nanoparticles for cancer applications (LITA-CAN). We assessed chronic in vivo administration of our nanoparticle in three separate murine models of colorectal cancer. We demonstrated a substantial reduction in tumor growth in the xenograft model of colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53-/-. Nanoparticle-induced reductions in histone deacetylase gene expression indicated a potential mechanism for these anti-proliferative effects. Together, these results indicated that LITA-CAN could be used as an effective direct or adjunct therapy to treat malignant transformation in vivo.

Item Type: Article
Uncontrolled Keywords: lipid-based nanoparticles, liposomes, cancer, short-chain fatty acids, epigenetics;
Subjects: University of Westminster > Science and Technology
SWORD Depositor: repository@westminster.ac.uk
Depositing User: repository@westminster.ac.uk
Date Deposited: 14 Sep 2017 09:01
Last Modified: 14 Sep 2017 09:01
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/19757

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