In vitro determination of skin bilirubin using chromatic modulation

Tomtsis, Dimitris and Kodogiannis, Vassilis and Zissopoulos, D. (2001) In vitro determination of skin bilirubin using chromatic modulation. In: Building new bridges at the frontiers of engineering and medicine: 2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 25-28 October 2001, Istanbul, Turkey. IEEE Computer Society, USA, pp. 3946-3949. ISBN 0780372115


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A clinical examination system is presented to analyse the yellowness presented on the skin of premature newborn babies, namely transcutaneous bilirubin (TcB). The system is based on chromatic modulation methods to extract, process and analyse data in order to determine the spectral chromaticity of a baby's tissue without taking blood samples. Chromatic bilirubin monitoring tests have shown a high correlation and a linear relationship between serum bilirubin (SB) and a chromatic parameter, namely Hugh angle (H). The chromatic TcB results are highly predictive of SB levels in neonatal babies. The proposed chromatic system can be used to make decisions about transfusions or phototherapy in neonates, hence acting as a screening device to determine when a laboratory assessment of SB is needed.

Item Type: Book Section
Uncontrolled Keywords: Chromatic modulation, chromaticity, remote monitoring, skin bilirubin, serum bilirubin, newborn babies
Subjects: University of Westminster > Science and Technology > Electronics and Computer Science, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 26 Jun 2006
Last Modified: 11 Aug 2010 14:30

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