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Intracranial identification of an electric frontal-cortex response to auditory stimulus change: a case study

Liasis, Alki and Towell, Anthony and Alho, K. and Boyd, Stewart (2001) Intracranial identification of an electric frontal-cortex response to auditory stimulus change: a case study. Cognitive Brain Research, 11 (2). pp. 227-233. ISSN 0926-6410

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Official URL: http://dx.doi.org/10.1016/S0926-6410(00)00077-X

Abstract

The aim of the present study was to clarify whether ERPs recorded directly from the human frontal cortex contributed to the auditory N1 and mismatch negativity (MMN) elicited by changes in non-phonetic and phonetic sounds. We examined the role of prefrontal cortex in the processing of stimulus repetition and change in a 6-year-old child undergoing presurgical evaluation for epilepsy. EEG was recorded from three bilateral sub-dural electrode strips located over lateral prefrontal areas during unattended auditory stimulation. EEG epochs were averaged to obtain event-related potentials (ERPs) to repeating (standard) tones and to infrequent (deviant) shorter duration tones and complex sounds (telephone buzz). In another condition, ERPs were recorded to standard and deviant syllables, /ba/ and /da/, respectively. ERPs to vibration stimuli delivered to the fingertips were not observed at any of the sub-dural electrodes, confirming modality specificity of the auditory responses. Focal auditory ERPs consisting of P100 and N150 deflections were recorded to both tones and phonemes over the right lateral prefrontal cortex. These responses were insensitive to the serial position of the repeating sound in the stimulus train. Deviant tones evoked an MMN peaking at around 128 ms. Deviant complex sounds evoked ERPs with a similar onset latency and morphology but with an approximately two-fold increase in peak-to-peak amplitude. We conclude that right lateral prefrontal cortex (Brodmann’s area 45) is involved in early stages of processing repeating sounds and sound changes.

Item Type:Article
Uncontrolled Keywords:Frontal lobe, Mismatch negativity, Auditory ERPs, Attention
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:218
Deposited On:29 Nov 2005
Last Modified:30 Oct 2009 12:09

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