Animal toxins: what features differentiate pore blockers from gate modifiers

Bhogal, Saranjit and Revett, Kenneth (2005) Animal toxins: what features differentiate pore blockers from gate modifiers. In: 2005 ICSC Congress on Computational Intelligence Methods and Applications. IEEE Computer Society, USA. ISBN 1424400201

[img]
Preview
PDF
Bhogal,_Revett_2005_final.pdf

Download (5MB)
Official URL: http://dx.doi.org/10.1109/CIMA.2005.1662329

Abstract

A surprisingly large number of animal toxins target voltage sensitive ion channels. Even though there exists toxins for all four major voltage sensitive ion channels, a majority act either on sodium or potassium channels. Given a specific primary sequence, the challenge is to determine in an automated fashion whether a given substance is toxic, and what its site of action might be. Currently, there are signals such as functional dyads that are indicative of a toxin, but are not yet specific enough to allow accurate prediction of the site of action. In this paper, an automated approach for detecting whether a toxin acts on voltage-sensitive sodium versus potassium channels is presented. In addition, our consensus sequence is also able to reliably determine whether the toxin acts as a gate modifier or pore blocker (> 93% accuracy).

Item Type: Book Section
Uncontrolled Keywords: Gate blocker, multiple sequence alignment, pore blocker, venom, voltage-sensitive ion channels
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
University of Westminster > Science and Technology > Electronics and Computer Science, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 28 Jun 2006
Last Modified: 11 Aug 2010 14:30
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/2217

Actions (login required)

Edit Item (Repository staff only) Edit Item (Repository staff only)

Downloads