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Animal toxins: what features differentiate pore blockers from gate modifiers

Bhogal, Saranjit and Revett, Kenneth (2005) Animal toxins: what features differentiate pore blockers from gate modifiers. In: 2005 ICSC Congress on Computational Intelligence Methods and Applications. IEEE Computer Society, USA. ISBN 1424400201


Official URL: http://dx.doi.org/10.1109/CIMA.2005.1662329


A surprisingly large number of animal toxins target voltage sensitive ion channels. Even though there exists toxins for all four major voltage sensitive ion channels, a majority act either on sodium or potassium channels. Given a specific primary sequence, the challenge is to determine in an automated fashion whether a given substance is toxic, and what its site of action might be. Currently, there are signals such as functional dyads that are indicative of a toxin, but are not yet specific enough to allow accurate prediction of the site of action. In this paper, an automated approach for detecting whether a toxin acts on voltage-sensitive sodium versus potassium channels is presented. In addition, our consensus sequence is also able to reliably determine whether the toxin acts as a gate modifier or pore blocker (> 93% accuracy).

Item Type:Book Section
Uncontrolled Keywords:Gate blocker, multiple sequence alignment, pore blocker, venom, voltage-sensitive ion channels
Research Community:University of Westminster > Life Sciences, School of
University of Westminster > Electronics and Computer Science, School of
ID Code:2217
Deposited On:28 Jun 2006
Last Modified:11 Aug 2010 15:30

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