Guyatt, Helen L. and Brooker, Simon and Kihamia, Charles M. and Hall, Andrew and Bundy, Donald A.P. (2001) Evaluation of efficacy of school-based anthelmintic treatments against anaemia in children in the United Republic of Tanzania. Bulletin of the World Health Organization, 79 (8). pp. 695-703. ISSN 0042-9686
Official URL: http://www.who.int/entity/bulletin/archives/79(8)6...
Objective: To determine the impact of deworming on anaemia as part of a large-scale school-based anthelmintic treatment programme in the Tanga Region of the United Republic of Tanzania. Methods: Both the reduction in the prevalence of anaemia and the cost per case prevented were taken into consideration. Cross-sectional studies involved parasitological examination and anaemia evaluation before and at 10 months and 15 months after schoolchildren were dewormed. Findings: Baseline studies indicated that the prevalence of anaemia (haemoglobin < 110 g/l) was high (54%) among schoolchildren, particularly those with high intensities of hookworm and schistosomiasis. Attributable fraction analysis suggested that hookworm and schistosomiasis were responsible for 6% and 15% of anaemia cases, respectively. Fifteen months after deworming with albendazole and praziquantel the prevalence of anaemia was reduced by a quarter and that of moderate-to-severe anaemia (haemoglobin <90 g/l) was reduced by nearly a half. The delivery of these anthelmintics through the school system was achieved at the relatively low cost of US$ 1 per treated child. The cost per anaemia case prevented by deworming schoolchildren was in the range US$ 6 - 8, depending on the haemoglobin threshold used. Conclusions: The results suggested that deworming programmes should be included in public health strategies for the control of anaemia in schoolchildren where there are high prevalences of hookworm and schistosomiasis.
|Additional Information:||Online ISSN 1564-0604|
|Uncontrolled Keywords:||Anthelmintics/therapeutic use, Albendazole/therapeutic use/administration and dosage, Praziquantel/ therapeutic use/administration and dosage, Anemia/parasitology, Hookworm infections/drug therapy/ complications, Schistosomiasis/drug therapy/complications, Child, School health services, Cross-sectional studies, Logistic models, Regression analysis, United Republic of Tanzania|
|Research Community:||University of Westminster > Life Sciences, School of|
|Deposited On:||05 Jul 2006|
|Last Modified:||11 Aug 2010 15:31|
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