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Evaluation of efficacy of school-based anthelmintic treatments against anaemia in children in the United Republic of Tanzania

Guyatt, Helen L. and Brooker, Simon and Kihamia, Charles M. and Hall, Andrew and Bundy, Donald A.P. (2001) Evaluation of efficacy of school-based anthelmintic treatments against anaemia in children in the United Republic of Tanzania. Bulletin of the World Health Organization, 79 (8). pp. 695-703. ISSN 0042-9686

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Official URL: http://www.who.int/entity/bulletin/archives/79(8)6...

Abstract

Objective: To determine the impact of deworming on anaemia as part of a large-scale school-based anthelmintic treatment programme in the Tanga Region of the United Republic of Tanzania. Methods: Both the reduction in the prevalence of anaemia and the cost per case prevented were taken into consideration. Cross-sectional studies involved parasitological examination and anaemia evaluation before and at 10 months and 15 months after schoolchildren were dewormed. Findings: Baseline studies indicated that the prevalence of anaemia (haemoglobin < 110 g/l) was high (54%) among schoolchildren, particularly those with high intensities of hookworm and schistosomiasis. Attributable fraction analysis suggested that hookworm and schistosomiasis were responsible for 6% and 15% of anaemia cases, respectively. Fifteen months after deworming with albendazole and praziquantel the prevalence of anaemia was reduced by a quarter and that of moderate-to-severe anaemia (haemoglobin <90 g/l) was reduced by nearly a half. The delivery of these anthelmintics through the school system was achieved at the relatively low cost of US$ 1 per treated child. The cost per anaemia case prevented by deworming schoolchildren was in the range US$ 6 - 8, depending on the haemoglobin threshold used. Conclusions: The results suggested that deworming programmes should be included in public health strategies for the control of anaemia in schoolchildren where there are high prevalences of hookworm and schistosomiasis.

Item Type:Article
Additional Information:Online ISSN 1564-0604
Uncontrolled Keywords:Anthelmintics/therapeutic use, Albendazole/therapeutic use/administration and dosage, Praziquantel/ therapeutic use/administration and dosage, Anemia/parasitology, Hookworm infections/drug therapy/ complications, Schistosomiasis/drug therapy/complications, Child, School health services, Cross-sectional studies, Logistic models, Regression analysis, United Republic of Tanzania
Research Community:University of Westminster > Life Sciences, School of
ID Code:2385
Deposited On:05 Jul 2006
Last Modified:11 Aug 2010 15:31

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