Bland, Elliot James and Keshavarz, Tajalli and Bucke, Christopher (2004) The influence of small oligosaccharides on the immune system. Carbohydrate Research, 339 (10). pp. 1673-1678. ISSN 0008-6215
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Official URL: http://dx.doi.org/10.1016/j.carres.2004.05.009
In this study, oligosaccharides known to enhance the synthesis of penicillin by Penicillium chrysogenum have been presented to human immune cells and their effect measured. In addition a range of commercially available oligosaccharides have been tested. Results obtained indicate that oligosaccharides with a degree of polymerisation greater than 6 and with a tendency to form helical structures are most effective at influencing the immune system as measured by the production of reactive oxidising species. Laminariheptaose has been shown to increase reactive oxidising species production by up to 25%, whilst mannan-oligosaccharides with a DP of 6 to 7 decrease production by up to 44%. These and other results show that the immune system can recognise subtle differences in oligosaccharides and that these oligosaccharides could potentially be used to modulate the immune response.
|Uncontrolled Keywords:||Immunomodulation; Oligosaccharides; Carbohydrates; Reactive oxygen species; Reactive oxidising species|
|Research Community:||University of Westminster > Life Sciences, School of|
|Deposited On:||13 Jul 2006|
|Last Modified:||11 Dec 2009 11:50|
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