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Ion-dependency of the streptococcal deoxyribonuclease "streptodornase", an active constituent of the medicament Varidase

Locke, Ian C. and Carpenter, Brian (2002) Ion-dependency of the streptococcal deoxyribonuclease "streptodornase", an active constituent of the medicament Varidase. Enzyme and Microbial Technology, 31 (4). pp. 482-489. ISSN 0141-0229

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Official URL: http://dx.doi.org/10.1016/S0141-0229(02)00125-4

Abstract

The activity of streptodornase, a deoxyribonuclease active protein component of the medicament Varidase® has been shown to be dependant on the presence and concentration of certain cation species. Anion species appear to have little effect on streptodornase activity. In particular, the divalent cations magnesium and calcium are essential for optimum activity whilst sodium ions are inhibitory. The overall effect of ion concentration on streptodornase activity is a result of a complex interplay between the various ion species. These effects and conditions are described and a possible explanation for the observed interplay is offered.

Item Type:Article
Uncontrolled Keywords:Varidase®, Streptodornase, Deoxyribonuclease, Cations
Research Community:University of Westminster > Life Sciences, School of
ID Code:310
Deposited On:01 Dec 2005
Last Modified:11 Dec 2009 11:31

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