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Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii

Huang, Lan and Hung, Liwei and Odell, Mark and Yokota, Hisao and Kim, Rosalind and Kim, Sung-Hou (2002) Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii. Journal of Structural and Functional Genomics, 2 (3). pp. 121-127. ISSN 1345-711X

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Official URL: http://dx.doi.org/10.1023/A:1021279113558

Abstract

We have determined the three-dimensional (3-D) structure of protein MJ0882, which derives from a hypothetical open reading frame in the genome of the hyperthermophile Methanococcus jannaschii. The 3-D fold of MJ0882 at 1.8 Å highly resembles that of a methyltransferase, despite limited sequence similarity to any confirmed methyltransferase. The structure has an S-adenosylmethionine (AdoMet) binding pocket surrounded by motifs with similarities to those commonly found among AdoMet binding proteins. Preliminary biochemical experiments show that MJ0882 specifically binds to AdoMet, which is the essential co-factor for methyltransferases.

Item Type:Article
Additional Information:Online ISSN 1570-0267
Research Community:University of Westminster > Life Sciences, School of
ID Code:331
Deposited On:01 Dec 2005
Last Modified:12 Oct 2009 16:43

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