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Identification of Streptococcus gallolyticus subsp. macedonicus as the etiological agent in a case of culture-negative multivalve infective endocarditis by 16S rDNA PCR analysis of resected valvular tissue

Malkin, Joanne and Kimmitt, Patrick T. and Ou, Hong-Yu and Bhasker, Pretti S. Santi and Khare, Milind and Deng, Zixin and Stephenson, Iain and Sosnowski, Andrew W. and Perera, Nelun and Rajakumar, Kumar (2008) Identification of Streptococcus gallolyticus subsp. macedonicus as the etiological agent in a case of culture-negative multivalve infective endocarditis by 16S rDNA PCR analysis of resected valvular tissue. Journal of Heart Valve Disease, 17 (5). pp. 589-592. ISSN 0966-8519

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Official URL: http://www.icr-heart.com/journal/content/2008/sept...

Abstract

Today, PCR using broad-range primers is being used increasingly to detect pathogens from resected heart valves. Herein is described the first case of multivalve infective endocarditis where 16S rDNA PCR was used to detect a single pathogen from two affected valves in a 61-year-old man. Triple heart valve replacement was required despite six weeks of appropriate antimicrobial therapy. The organism was confirmed as Streptococcus gallolyticus subsp. macedonicus, a member of the 'S. equinus/S. bovis' complex. To date, only one report has been made of human infection due to this organism. This may be due to the limited resolution of the routine diagnostic methods used and/or as a consequence of the complex nomenclature associated with this group of organisms.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:6234
Deposited On:26 Mar 2009 15:11
Last Modified:26 Mar 2009 15:11

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