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Minor physical anomalies in patients with first-episode psychosis: their frequency and diagnostic specificity

Lloyd, Tuhina and Dazzan, Paola and Dean, Kimberlie and Park, S.B.G. and Fearon, Paul and Doody, Gillian A. and Tarrant, Jane and Morgan, Kevin D. and Morgan, Craig and Hutchinson, Gerard and Leff, Julian and Harrison, Glynn and Murray, Robin M. and Jones, Peter B. (2008) Minor physical anomalies in patients with first-episode psychosis: their frequency and diagnostic specificity. Psychological Medicine, 38 (1). pp. 71-77. ISSN 0033-2917

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Official URL: http://dx.doi.org/10.1017/S0033291707001158

Abstract

Background. An increased prevalence of minor physical anomalies (MPAs) has been extensively documented in schizophrenia but their specificity for the disorder remains unclear. We investigated the prevalence and the predictive power of MPAs in a large sample of first-episode psychotic patients across a range of diagnoses. Method. MPAs were examined in 242 subjects with first-episode psychosis (50% schizophrenia, 45% affective psychosis and 5% substance-induced psychosis) and 158 healthy controls. Categorical principal components analysis and analysis of variance were undertaken, and individual items with the highest loading were tested using the chi(2) test. Results. Overall facial asymmetry, assymetry of the orbital landmarks, and frankfurt horizontal significantly differentiated patients with schizophrenia and affective psychosis from controls, as did a 'V-shaped' palate, reduced palatal ridges, abnormality of the left ear surface and the shape of the left and right ears. Patients with affective psychosis had significantly lowered eye fissures compared with control subjects. Conclusions. MPAs are not specific to schizophrenia, suggesting a common developmental pathway for non-affective and affective psychoses. The topographical distribution of MPAs in this study is suggestive of an insult occurring during organogenesis in the first trimester of pregnancy.

Item Type:Article
Uncontrolled Keywords:Affective psychosis, anthropometric, developmental marker, diagnostic specificity, first-episode psychosis, minor physical anomalies, schizophrenia
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:6701
Deposited On:30 Apr 2009 12:15
Last Modified:30 Apr 2009 12:15

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