Neurological abnormalities and cognitive ability in first-episode psychosis

Dazzan, Paola, Lloyd, Tuhina, Morgan, Kevin D., Zanelli, Jolanta, Morgan, Craig, Orr, Kenneth G., Hutchinson, Gerard, Fearon, Paul, Allin, Matthew, Rifkin, Larry, McGuire, Philip K., Doody, Gillian A., Holloway, John, Leff, Julian, Harrison, Glynn, Jones, Peter B. and Murray, Robin M. (2008) Neurological abnormalities and cognitive ability in first-episode psychosis. British Journal of Psychiatry, 193 (3). pp. 197-202. ISSN 1472-1465

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Background it remains unclear if the excess of neurological soft signs, or of certain types of neurological soft signs, is common to all psychoses, and whether this excess is simply an epiphenomenon of the lower general cognitive ability present in psychosis. Aims To investigate whether an excess of neurological soft signs is independent of diagnosis (schizophrenia v. affective psychosis) and cognitive ability (IQ). Method Evaluation of types of neurological soft signs in a prospective cohort of all individuals presenting with psychoses over 2 years (n=310), and in a control group from the general population (n=239). Results Primary (P < 0.001), motor coordination (P < 0.001), and motor sequencing (P < 0.001) sign scores were significantly higher in people with any psychosis than in the control group. However, only primary and motor coordination scores remained higher when individuals with psychosis and controls were matched for premorbid and current IQ. Conclusions Higher rates of primary and motor coordination signs are not associated with lower cognitive ability, and are specific to the presence of psychosis.

Item Type: Article
Uncontrolled Keywords: Soft signs, neuropsychological performance, diagnostic specificity, schizophrenic-patients episode schizophrenia, bipolar disorder, dysfunction, AESOP
Subjects: University of Westminster > Social Sciences and Humanities
Depositing User: Miss Nina Watts
Date Deposited: 30 Apr 2009 11:24
Last Modified: 30 Apr 2009 11:24

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