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In vitro production of polyhydroxyalkanoates: achievements and applications

Thomson, Nicholas and Roy, Ipsita and Summers, David and Sivaniah, Easan (2010) In vitro production of polyhydroxyalkanoates: achievements and applications. Journal of Chemical Technology and Biotechnology, 85 (6). pp. 760-767. ISSN 0268-2575

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Official URL: http://dx.doi.org/10.1002/jctb.2299


The mechanisms of polyhydroxyalkanoate (PHA) production have been studied for over half a century. However, despite numerous improvements in the control of monomer composition, genetically-engineered host organisms, fermentation strategies and polymer recovery processes they remain uncompetitive compared with petrochemical plastics. Recently, interest has developed in the enzyme-catalysed production of PHAs in vitro. This has allowed the study of enzyme kinetics and properties, and represents another strategy for the economic production of PHAs on the industrial scale. It also presents an opportunity to coat other materials in thin films of PHA so as to modify the surface properties. In vitro production offers advantages over in vivo methods as it enables greater control over monomer composition and molecular weight, does not require a biomass-accumulation phase, simplifies downstream processing and can utilise a wider range of monomeric subunits.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:7112
Deposited On:06 Jan 2010 12:46
Last Modified:26 May 2010 11:12

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