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Electrospun nanofibrous biodegradable polyester coatings on Bioglass®-based glass-ceramics for tissue engineering

Bretcanu, Oana and Misra, Superb K. and Yunos, D. Mohammad and Boccaccini, Aldo R. and Roy, Ipsita and Kowalczyk, Tomasz and Blonski, Slawomir and Kowalewski, Tomasz A. (2009) Electrospun nanofibrous biodegradable polyester coatings on Bioglass®-based glass-ceramics for tissue engineering. Materials Chemistry and Physics, 118 (2-3). pp. 420-426. ISSN 0254-0584

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Official URL: http://dx.doi.org/10.1016/jmatchemphys.2009.08.01

Abstract

Biodegradable polymeric nanofibrous coatings were obtained by electrospinning different polymers onto sintered 45S5 Bioglass®-based glass-ceramic pellets. The investigated polymers were poly(3-hydroxybutyrate) (P3HB), poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV) and a composite of poly(caprolactone) (PCL) and poly(ethylene oxide) (PEO) (PCL–PEO). The fibrous coatings morphology was evaluated by optical microscopy and scanning electron microscopy. The electrospinning process parameters were optimised to obtain reproducible coatings formed by a thin web of polymer nanofibres. In-vitro studies in simulated body fluid (SBF) were performed to investigate the bioactivity and mineralisation of the substrates by inducing the formation of hydroxyapatite (HA) on the nanofiber-coated pellets. HA crystals were detected on all samples after 7 days of immersion in SBF, however the morphology of the HA layer depended on the characteristic fibre diameter, which in turn was a function of the specific polymer-solvent system used. The bioactive and resorbable nanofibrous coatings can be used to tailor the surface topography of bioactive glass-ceramics for applications in tissue engineering scaffolds.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:7114
Deposited On:06 Jan 2010 12:57
Last Modified:06 Jan 2010 12:57

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