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Effect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites

Misra, Superb K. and Ansari, Tahera and Mohn, Dirk and Valappil, Sabeel P. and Brunner, Tobias J. and Stark, Wendelin J. and Roy, Ipsita and Knowles, Jonathan C. and Sibbons, Paul D. and Valsami-Jones, Eugenia and Boccaccini, Aldo R. and Salih, Vehid (2010) Effect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites. Journal of the Royal Society Interface, 7 (44). pp. 453-465. ISSN 1742-5689

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Official URL: http://dx.doi.org/10.1098/rsif.2009.0255

Abstract

This work investigated the effect of adding nanoparticulate (29 nm) bioactive glass particles on the bioactivity, degradation and in vitro cytocompatibility of poly(3-hydroxybutyrate) (P(3HB)) composites/nano-sized bioactive glass (n-BG). Two different concentrations (10 and 20 wt %) of nanoscale bioactive glass particles of 45S5 Bioglass composition were used to prepare composite films. Several techniques (Raman spectroscopy, scanning electron microscopy, atomic force microscopy, energy dispersive X-ray) were used to monitor their surface and bioreactivity over a 45-day period of immersion in simulated body fluid (SBF). All results suggested the P(3HB)/n-BG composites to be highly bioactive, confirmed by the formation of hydroxyapatite on material surfaces upon immersion in SBF. The weight loss and water uptake were found to increase on increasing bioactive glass content. Cytocompatibility study (cell proliferation, cell attachment, alkaline phosphatase activity and osteocalcin production) using human MG-63 osteoblast-like cells in osteogenic and non-osteogenic medium showed that the composite substrates are suitable for cell attachment, proliferation and differentiation.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:7115
Deposited On:06 Jan 2010 13:03
Last Modified:01 Apr 2010 14:40

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