Misra, Superb K., Philip, Sheryl E., Chrzanowski, Wojciech, Nazhat, Showan N., Roy, Ipsita, Knowles, Jonathan C., Salih, Vehid and Boccaccini, Aldo R. (2009) Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment. Journal of the Royal Society Interface, 6 (33). pp. 401-409. ISSN 1742-5689Full text not available from this repository.
This study investigated the possibility of incorporating ?-tocopherol (vitamin E) into poly(3hydroxybutyrate) (P(3HB))/Bioglass composites, which are being developed for bone tissue engineering matrices. P(3HB) films with 20?wt% Bioglass and 10?wt% vitamin E were prepared using the solvent casting technique. Addition of vitamin E significantly improved the hydrophilicity of the composites along with increasing the total protein adsorption. The presence of protein adsorbed on the composite surface was further confirmed using X-ray photoelectron spectroscopy analysis. Preliminary cell culture studies using MG-63 human osteoblasts showed that the addition of vitamin E in the P(3HB)/20?wt% Bioglass films significantly increased cell proliferation. The results achieved in this study confirmed the possibility of incorporating vitamin E as a suitable additive in P(3HB)/Bioglass composites to engineer the surface of the composites by promoting higher protein adsorption and increasing the hydrophilicity.
|Subjects:||University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)|
|Depositing User:||Miss Nina Watts|
|Date Deposited:||06 Jan 2010 13:09|
|Last Modified:||06 Jan 2010 13:09|
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