Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment

Misra, S.K., Philip, S.E., Chrzanowski, W., Nazhat, S.N., Roy, I., Knowles, J.C., Salih, V. and Boccaccini, A.R. (2009) Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment. Journal of the Royal Society Interface, 6 (33). pp. 401-409. ISSN 1742-5689

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Official URL: https://dx.doi.org/10.1098/rsif.2008.0278

Abstract

This study investigated the possibility of incorporating α-tocopherol (vitamin E) into poly(3hydroxybutyrate) (P(3HB))/Bioglass composites, which are being developed for bone tissue engineering matrices. P(3HB) films with 20 wt% Bioglass and 10 wt% vitamin E were prepared using the solvent casting technique. Addition of vitamin E significantly improved the hydrophilicity of the composites along with increasing the total protein adsorption. The presence of protein adsorbed on the composite surface was further confirmed using X-ray photoelectron spectroscopy analysis. Preliminary cell culture studies using MG-63 human osteoblasts showed that the addition of vitamin E in the P(3HB)/20 wt% Bioglass films significantly increased cell proliferation. The results achieved in this study confirmed the possibility of incorporating vitamin E as a suitable additive in P(3HB)/Bioglass composites to engineer the surface of the composites by promoting higher protein adsorption and increasing the hydrophilicity.

Item Type: Article
Subjects: University of Westminster > Science and Technology
SWORD Depositor: repository@westminster.ac.uk
Depositing User: repository@westminster.ac.uk
Date Deposited: 06 Jan 2010 13:09
Last Modified: 04 Oct 2017 14:46
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/7116

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