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Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment

Misra, Superb K. and Philip, Sheryl E. and Chrzanowski, Wojciech and Nazhat, Showan N. and Roy, Ipsita and Knowles, Jonathan C. and Salih, Vehid and Boccaccini, Aldo R. (2009) Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment. Journal of the Royal Society Interface, 6 (33). pp. 401-409. ISSN 1742-5689

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Official URL: http://dx.doi.org/10.1098/rsif.2008.0278

Abstract

This study investigated the possibility of incorporating α-tocopherol (vitamin E) into poly(3hydroxybutyrate) (P(3HB))/Bioglass composites, which are being developed for bone tissue engineering matrices. P(3HB) films with 20 wt% Bioglass and 10 wt% vitamin E were prepared using the solvent casting technique. Addition of vitamin E significantly improved the hydrophilicity of the composites along with increasing the total protein adsorption. The presence of protein adsorbed on the composite surface was further confirmed using X-ray photoelectron spectroscopy analysis. Preliminary cell culture studies using MG-63 human osteoblasts showed that the addition of vitamin E in the P(3HB)/20 wt% Bioglass films significantly increased cell proliferation. The results achieved in this study confirmed the possibility of incorporating vitamin E as a suitable additive in P(3HB)/Bioglass composites to engineer the surface of the composites by promoting higher protein adsorption and increasing the hydrophilicity.

Item Type:Article
Research Community:University of Westminster > Life Sciences, School of
ID Code:7116
Deposited On:06 Jan 2010 13:09
Last Modified:06 Jan 2010 13:09

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