Microbial PHA biosynthesis and its biomedical applications

Roy, Ipsita, Philip, Sheryl E., Francis, Lydia, Rai, Ranjana, Keshavarz, Tajalli, Misra, Superb K., Decheng, Meng and Boccaccini, Aldo R. (2009) Microbial PHA biosynthesis and its biomedical applications. In: Proceedings of Euromat 2009, Glasgow, 7 - 10 September 2009. Euromat.

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Polyhydroxyalkanoates (PHAs), are polyesters of 3-, 4- 5- and 6-hydroxyalkanoic acids, produced by a variety of bacterial species under nutrient-limiting conditions with excess carbon[1]. PHA production by Bacillus cereus SPV and Pseudomonas sp. has been explored under different nutrient limiting conditions[2]. Bacillus cereus SPV has been found to produce maximum PHA under nitrogen limiting conditions. Interestingly P(3HB-co-3HV) production was obtained using glucose under potassium-limiting conditions[2]. The Pseudomonas sp. have also been found to utilise a range of different carbon sources including structurally related fatty acids and structurally unrelated carbohydrates. Mcl-PHAs produced include P(3HO), P3(HHX-co-HO-co-HD) and the previously unknown novel mcl-PHA, P(3HO-co-2HDD). The PHAs produced have been used for the production of tissue engineering scaffolds and drug delivery structures with and without Bioglass®[3]. The microstructure, bioactivity and drug release kinetics have been studied. PHA composites with micro-sized bioactive glass (m-BG) have been compared to composites with nano-sized bioactive glass (n-BG)[4]. The incorporation of n-BG particles had a significant reinforcing effect on the composite due to enhancement of the elastic modulus as a function of the n-BG content.

Item Type: Book Section
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 07 Jan 2010 12:01
Last Modified: 07 Jan 2010 12:01
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/7130

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