Milton, Nathaniel G.N. and Mayor, Neema P. and Rawlinson, John (2001) Identification of amyloid-ß binding sites using an antisense peptide approach. NeuroReport, 12 (11). pp. 2561-2566. ISSN 0959-4965
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The amyloid-[beta] (A[beta]) peptide is a cytotoxic peptide implicated in the pathology of Alzheimer's disease (AD). Catalase and the endoplasmic reticulum A[beta] binding dehydrogenase (ERAB) are both inhibited by characterized fragments of the A[beta] peptide. In order to target such proteins it is essential to determine which components of these enzymes interact with A[beta]. This study reports the use of antisense peptide methodology to identify specific A[beta]-binding domains. Synthetic peptides corresponding to the regions of catalase and ERAB identified showed specific binding to A[beta] and also prevented A[beta] cytotoxicity. Antisense peptide methodology has identified A[beta] recognition sequences and may also be applied to the identification of novel A[beta] protein interactions to identify targets for use in the treatment of AD.
|Research Community:||University of Westminster > Life Sciences, School of|
|Deposited On:||26 Jan 2010 15:53|
|Last Modified:||26 Jan 2010 15:53|
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