Misra, Superb K. and Ansari, Tahera I. and Valappil, Sabeel P. and Mohn, Dirk and Philip, Sheryl E. and Stark, Wendelin J. and Roy, Ipsita and Knowles, Jonathan C. and Salih, Vehid and Boccaccini, Aldo R. (2010) Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications. Biomaterials, 31 (10). pp. 2806-2815. ISSN 0142-9612
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Official URL: http://dx.doi.org/10.1016/j.biomaterials.2009.12.0...
Poly(3-hydroxybutyrate) (P(3HB)) foams exhibiting highly interconnected porosity (85% porosity) were prepared using a unique combination of solvent casting and particulate leaching techniques by employing commercially available sugar cubes as porogen. Bioactive glass (BG) particles of 45S5 Bioglass((R)) grade were introduced in the scaffold microstructure, both in micrometer ((m-BG), <5 mum) and nanometer ((n-BG), 30 nm) sizes. The in vitro bioactivity of the P(3HB)/BG foams was confirmed within 10 days of immersion in simulated body fluid and the foams showed high level of protein adsorption. The foams interconnected porous microstructure proved to be suitable for MG-63 osteoblast cell attachment and proliferation. The foams implanted in rats as subcutaneous implants resulted in a non-toxic and foreign body response after one week of implantation. In addition to showing bioactivity and biocompatibility, the P(3HB)/BG composite foams also exhibited bactericidal properties, which was tested on the growth of Staphylococcus aureus. An attempt was made at developing multifunctional scaffolds by incorporating, in addition to BG, selected concentrations of Vitamin E or/and carbon nanotubes. P(3HB) scaffolds with multifunctionalities (viz. bactericidal, bioactive, electrically conductive, antioxidative behaviour) were thus produced, which paves the way for next generation of advanced scaffolds for bone tissue engineering. Copyright © 2009 Elsevier Ltd. All rights reserved.
|Research Community:||University of Westminster > Life Sciences, School of|
|Deposited On:||02 Feb 2010 11:57|
|Last Modified:||11 Mar 2010 14:27|
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