Cholesterol in Alzheimer's disease and other amyloidogenic disorders

Harris, J. Robin and Milton, Nathaniel G.N. (2010) Cholesterol in Alzheimer's disease and other amyloidogenic disorders. Subcellular Biochemistry, 51. pp. 47-75. ISSN 0306-0225

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The complex association of cholesterol metabolism and Alzheimer’s disease is presented in depth, including the possible benefits to be gained from cholesterol-lowering statin therapy. Then follows a survey of the role of neuronal membrane cholesterol in A? pore formation and A? fibrillogenesis, together with the link with membrane raft domains and gangliosides. The contribution of structural studies to A? fibrillogenesis, using TEM and AFM, is given some emphasis. The role of apolipoprotein E and its isoforms, in particular ApoE4, in cholesterol and A? binding is presented, in relation to genetic risk factors for Alzheimer’s disease. Increasing evidence suggests that cholesterol oxidation products are of importance in generation of Alzheimer’s disease, possibly induced by A?-produced hydrogen peroxide. The body of evidence for a link between cholesterol in atherosclerosis and Alzheimer’s disease is increasing, along with an associated inflammatory response. The possible role of cholesterol in tau fibrillization, tauopathies and in some other non-A? amyloidogenic disorders is surveyed.

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 18 Mar 2010 09:28
Last Modified: 01 Jul 2010 13:49

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