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State associations with the cortisol awakening response in healthy females

Stalder, Tobias and Evans, Philip D. and Hucklebridge, Frank and Clow, Angela (2010) State associations with the cortisol awakening response in healthy females. Psychoneuroendocrinology, 35 (8). pp. 1245-1252. ISSN 0306-4530

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Official URL: http://dx.doi.org/10.1016/j.psyneuen.2010.02.014


The current study examined intra-individual relationships between the cortisol awakening response (CAR) and state sleep-related and psychosocial variables in a pooled design study. 12 healthy female participants (age range: 22-41 years.) were examined on 12 study days each, occurring at three-day intervals. Quantitative diaries capturing state sleep-related and psychosocial variables were filled out on the evening before each study day as well as 45min post-awakening on the study day. On each study day, salivary free cortisol was determined at 0, 15, 30, and 45min post-awakening. Relationships between cortisol measures and psychosocial variables were analysed using dummy-variable linear regression models. State variability in the CAR (area under increase curve; AUC(I)) was found to be inversely related to simultaneous variability in awakening time (beta=-.29, p<.005) and positively related to variability in adverse psychosocial states of stress (beta=.22, p<.01) and tension (beta=.32, p<.001) measured 45min post-awakening. In addition, levels of the CAR were also found to decrease linearly over the study period across participants (beta=-.19, p<.01) and this time trend could not be explained through a relationship between the CAR and any of the examined variables. The results are discussed within the context of previous evidence and potential implications for cross-sectional research are highlighted.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
University of Westminster > Life Sciences, School of
ID Code:7822
Deposited On:25 Mar 2010 14:14
Last Modified:20 Sep 2010 16:17

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