Minati, Ludovico and Edginton, Trudi L. and Bruzzone, Maria Grazia and Giaconne, G. (2009) Current concepts in Alzheimer's disease: a multidisciplinary review. American Journal of Alzheimer's Disease and Other Dementias, 24 (2). pp. 95-121. ISSN 1533-3175Full text not available from this repository.
This comprehensive, pedagogically-oriented review is aimed at a heterogeneous audience representative of the allied disciplines involved in research and patient care. After a foreword on epidemiology, genetics, and risk factors, the amyloid cascade model is introduced and the main neuropathological hallmarks are discussed. The progression of memory, language, visual processing, executive, attentional, and praxis deficits, and of behavioral symptoms is presented. After a summary on neuropsychological assessment, emerging biomarkers from cerebrospinal fluid assays, magnetic resonance imaging, nuclear medicine, and electrophysiology are discussed. Existing treatments are briefly reviewed, followed by an introduction to emerging disease-modifying therapies such as secretase modulators, inhibitors of Abeta aggregation, immunotherapy, inhibitors of tau protein phosphorylation, and delivery of nerve growth factor.
|Subjects:||University of Westminster > Social Sciences and Humanities|
|Depositing User:||Miss Nina Watts|
|Date Deposited:||16 Jul 2010 08:58|
|Last Modified:||11 Jun 2012 09:47|
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