WestminsterResearch

Current concepts in Alzheimer's disease: a multidisciplinary review

Minati, Ludovico and Edginton, Trudi L. and Bruzzone, Maria Grazia and Giaconne, G. (2009) Current concepts in Alzheimer's disease: a multidisciplinary review. American Journal of Alzheimer's Disease and Other Dementias, 24 (2). pp. 95-121. ISSN 1533-3175

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Official URL: http://dx.doi.org/10.1177/1533317508328602

Abstract

This comprehensive, pedagogically-oriented review is aimed at a heterogeneous audience representative of the allied disciplines involved in research and patient care. After a foreword on epidemiology, genetics, and risk factors, the amyloid cascade model is introduced and the main neuropathological hallmarks are discussed. The progression of memory, language, visual processing, executive, attentional, and praxis deficits, and of behavioral symptoms is presented. After a summary on neuropsychological assessment, emerging biomarkers from cerebrospinal fluid assays, magnetic resonance imaging, nuclear medicine, and electrophysiology are discussed. Existing treatments are briefly reviewed, followed by an introduction to emerging disease-modifying therapies such as secretase modulators, inhibitors of Abeta aggregation, immunotherapy, inhibitors of tau protein phosphorylation, and delivery of nerve growth factor.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:8302
Deposited On:16 Jul 2010 09:58
Last Modified:11 Jun 2012 10:47

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