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Insight, grey matter and cognitive function in first-onset psychosis

Morgan, Kevin D. and Dazzan, Paola and Morgan, Craig and Lappin, Julia M. and Hutchinson, Gerard and Suckling, John and Fearon, Paul and Jones, Peter B. and Leff, Julian and Murray, Robin M. and David, Anthony S. (2010) Insight, grey matter and cognitive function in first-onset psychosis. British Journal of Psychiatry, 197 (2). pp. 141-148. ISSN 0007-1250

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Official URL: http://dx.doi.org/10.1192/bjp.bp.109.070888

Abstract

BACKGROUND: Several studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures. AIMS: Focusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis. METHOD: Voxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight. RESULTS: The principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus. CONCLUSIONS: The cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:8531
Deposited On:07 Oct 2010 09:29
Last Modified:07 Oct 2010 09:29

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