Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures

Sorrentino, Flavia and Roy, Ipsita and Keshavarz, Tajalli (2010) Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures. Applied Microbiology and Biotechnology, 88 (1). pp. 65-73. ISSN 0175-7598

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Official URL: http://dx.doi.org/10.1007/s00253-010-2722-0

Abstract

This work proposes a novel approach for enhancing the yield of lovastatin in Aspergillus terreus cultures by exploiting linoleic acid-derived signalling molecules, which are potentially involved in fungal cell– cell communication. High-performance liquid chromatography analysis revealed that production of lovastatin was enhanced up to 1.8-fold upon exogenous addition of the oxylipin precursor linoleic acid to low cell density cultures of A. terreus. Real-time PCR analysis showed that supplementation of linoleic acid also resulted in an increase in transcriptional levels of lovastatin biosynthetic genes lovB and lovF, indicating a transcriptional control of fatty acids (linoleic acid) on these genes in A. terreus. This study therefore demonstrates for the first time the potential of an oxylipin molecule as an enhancer of a fungal secondary metabolite production with positive impact for industrial exploitation.

Item Type: Article
Subjects: University of Westminster > Science and Technology > Life Sciences, School of (No longer in use)
Depositing User: Miss Nina Watts
Date Deposited: 20 Sep 2010 15:04
Last Modified: 20 Sep 2010 15:04
URI: http://westminsterresearch.wmin.ac.uk/id/eprint/8622

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