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Data requirements in a model of the natural history of Alzheimer's disease

Chaussalet, Thierry J. and Thompson, Wayne A. (2001) Data requirements in a model of the natural history of Alzheimer's disease. Health Care Management Science, 4 (1). pp. 13-19. ISSN 1386-9620

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Official URL: http://dx.doi.org/10.1023/A:1009689329661

Abstract

The 'natural history' of Alzheimer's disease (AD) is discussed in terms of the data required in a general, discrete-time, non-homogeneous Markov model. The proposed model differs from similar models reported in the literature because mortality is disaggregated into AD-specific mortality and competing mortality due to other causes. Data are reviewed from the literature for AD incidence, and rates of disease progression and mortality. We conduct a preliminary sensitivity analysis using the reviewed data as base-case. The model shows that survival is sensitive to the modelling assumptions concerning mortality. This observation could have important consequences for studies that assess the cost of care following therapeutic interventions.

Item Type:Article
Additional Information:Online ISSN 1572-9389
Research Community:University of Westminster > Electronics and Computer Science, School of
ID Code:944
Deposited On:01 Dec 2005
Last Modified:19 Oct 2009 13:00

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