Chaussalet, Thierry J. and Thompson, Wayne A. (2001) Data requirements in a model of the natural history of Alzheimer's disease. Health Care Management Science, 4 (1). pp. 13-19. ISSN 1386-9620
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Official URL: http://dx.doi.org/10.1023/A:1009689329661
The 'natural history' of Alzheimer's disease (AD) is discussed in terms of the data required in a general, discrete-time, non-homogeneous Markov model. The proposed model differs from similar models reported in the literature because mortality is disaggregated into AD-specific mortality and competing mortality due to other causes. Data are reviewed from the literature for AD incidence, and rates of disease progression and mortality. We conduct a preliminary sensitivity analysis using the reviewed data as base-case. The model shows that survival is sensitive to the modelling assumptions concerning mortality. This observation could have important consequences for studies that assess the cost of care following therapeutic interventions.
|Additional Information:||Online ISSN 1572-9389|
|Research Community:||University of Westminster > Electronics and Computer Science, School of|
|Deposited On:||01 Dec 2005|
|Last Modified:||19 Oct 2009 13:00|
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