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Symmetric dimethylarginine (SDMA) is raised in women with polycystic ovary syndrome: a pilot study

Lakhani, K. and Kay, A.R. and Leiper, J. and Barry, John A. and Hardiman, Paul J. (2011) Symmetric dimethylarginine (SDMA) is raised in women with polycystic ovary syndrome: a pilot study. Journal of Obstetrics and Gynaecology, 31 (5). pp. 417-419. ISSN 0144-3615

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Official URL: http://dx.doi.org/10.3109/01443615.2011.569779

Abstract

Polycystic ovary syndrome (PCOS) is associated with endothelial dysfunction, which may be caused by elevated levels of asymmetric dimethylarginine (ADMA). ADMA reduces nitric oxide production in diabetes mellitus, hypertension and renal failure. Symmetric dimethylarginine (SDMA) is a stereoisomer produced alongside ADMA, and has recently been described as a risk factor for cardiovascular events. In this cross-sectional study based in a teaching hospital, 16 women with PCOS were recruited alongside 15 healthy controls, and fasting venous blood samples were obtained. Renal function was measured, and ADMA and SDMA were analysed using a high-performance liquid chromatography method. After controlling for BMI, mean ADMA and SDMA levels in women with PCOS were higher than in controls (p = 0.036 and p = 0.030, respectively). Renal function was not different between the two groups (p = 0.152). Women with PCOS have raised levels of SDMA, a molecule implicated in endothelial dysfunction and long-term cardiovascular risk.

Item Type:Article
Research Community:University of Westminster > Social Sciences, Humanities and Languages, School of
ID Code:9530
Deposited On:16 Jun 2011 11:39
Last Modified:16 Jun 2011 11:39

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